Neurodegenerative Diseases: Systems, Causes and Treatments

Neurodegenerative Diseases: Systems, Causes and Treatments Simon Mendy Compare the symptoms, causes and available or future treatments for Motor Neuron Disease, Spinal Muscular Atrophy and Myasthenia Gravis. Neurodegenerative diseases are hereditary (inherited) and sporadic (acquired during a person’s life) conditions caused by progressive nervous system dysfunction (http://ec.europa.eu/health/major_chronic_diseases/diseases/brain_neurological/index_en.htm). Motor neuron disease and Spinal Muscular Atrophy (shrink) are neurodegenerative conditions that arise due to motor neurons dysfunction and Myasthenia Gravis is an autoimmune neurodegenerative disorder. Motor neuron disease is caused by damage to motor neurons; Spinal muscular atrophy is due to deterioration of the motor neurons connecting the brain and spinal cord; Myasthenia gravis is an autoimmune condition that arises due to the damage or blocking of muscle receptors by antibodies accidently produced by the immune system. All three disorders result in weakness, making there diagnosis very hard, because weakness is a very common symptom of many conditions. However, possibilities are ruled out depending on the age of the pers on affected. If someone exhibiting muscle weakness is 1 year old, it is more likely that the person has SMA than the MG or MND, because SMA generally affects children ranging from less than six months to around the age of three, whereas MND is common in teenagers and young adults, and MG normally affects middle aged adults. Motor neurone disease is a unique condition of unknown aetiology that occurs when motor neurons (specialist nerve cells in the brain and spinal cord that relay signals from the brain to the muscles) become damaged and ultimately stop working (http://www.nhs.uk/conditions/Motor-neurone-disease/Pages/Introduction.aspx). This causes the muscles that the damage nerves supply to gradually lose strength, usually with wasting of muscles. It is unclear exactly what causes motor neurons to stop working, but, there is not thought to be a link with factors like lifestyle, race and diet. In a small number of cases (about 5%), there is a family history of either motor neuron disease or a related condition known as frontotemporal dementia. However, there is no single test to diagnose MND and diagnosis is solely based on the opinion of a neurologist, on the basis of the symptoms observed and a physical examination. In some cases a specialised test is needed to rule out other possible conditions. Symptoms of motor neurone disease begin gradually over a period of weeks and months, generally only on one side of the body at the beginning, and gradually get worse with time. Symptoms normally include having clumsy fingers or weaker grip (early signs of weakness). Other symptoms include: wasting of muscles, muscle cramps, hardships with swallowing and communication, excess saliva (difficulties swallowing saliva), and coughing after swallowing. After sometime, a person with motor neuron disease may find themselves unable to move. In a small number of cases (10-15%), motor neuron disease is associated with a type of dementia called frontotemporal dementia that can affect behaviour and personality. The main types of motor neuron disease are: amyotrophic lateral sclerosis (ALS) (accounts for 60-70% of all cases), progressive bulbar palsy (PBP), progressive muscular atrophy (PMA), and primary lateral sclerosis (PLS) (http://www.patient.co.uk/health/Motor-Neurone-Disease). Spinal muscular atrophy (SMA) is an autosomal (a chromosome that is not allosome) recessive genetic disease that causes muscle weakness and progressive loss of movement (http://www.fsma.org/FSMACommunity/understandingsma/WhatCausesSMA/). Around 1 out of every 40 people are genetic carriers of the disease (they carry the mutated gene but do not actually have SMA) (http://www.fsma.org/FSMACommunity/understandingsma/WhatCausesSMA/). Gene mutation is a permanent alteration in the DNA sequence that makes up a gene (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/genemutation). Gene mutation occurs in two different ways: they are either inherited from parents (known as hereditary mutation) or they are acquired at some time during a person’s life (known as acquired mutation). Hereditary mutations happen when mutations are present in both the egg and sperm cells. A person that has inherited this type of mutation has it present in virtually every cell in their body, throughout th eir lifetime. Acquired mutations occur in individual cells at some time during a person’s lifetime. These changes can occur due to environmental factors like ultraviolet (UV) light from the sun, chemicals, and radiation, or if a mistake is made whilst DNA copies itself during cell division (mitosis and meiosis). Acquired mutations are only inherited if they occur in sex cells. According to the National Genome Institute, almost all diseases have some kind of genetic factor. These disorders can be cause by multiple gene mutations, a mutation in a single gene, combined gene mutation and environmental factors, or by chromosome damage or mutation. Gene mutation has been identified as the cause of numerous disorders including spinal muscular atrophy (SMA), haemophilia, Tay-Sachs, sickle cell, anaemia, cystic fibrosis and some cancers (http://biology.about.com/od/basicgenetics/ss/gene-mutation.htm). The term SMA is used mainly for the most common form spinal muscular atrophy, which is caused by a genetic problem where one copy of the genetic error (mutation in autosomes) is inherited from each parent. SMA is classified into four different categories, from Type I IV. The classification of SMA depends on the age at which symptoms of the disease arise and the severity of the symptoms. Symptoms of SMA normally include problems with breathing, eating, moving and swallowing; floppy arms and legs (In children with either Type I or II SMA); twitching of the muscles in the arms, legs or tongue. Type I SMA is the most severe, it develops in babies under six months old. Type II is less severe that Type I SMA, it affects babies between the ages 6 to 18 months. Type III and Type IV are the mildest types of SMA. Type III normally affects children around 3 years old. Type IV affects adults. In the most severe cases of SMA (Types I and II), fatal respiratory problems usually develop during chi ldhood. In mild cases such as Types III and IV SMA, life expectancy is normally unaffected (http://www.nhs.uk/conditions/Spinal-muscular-atrophy/Pages/Introduction.aspx). Spinal muscular atrophy is caused by the deletion of the survival motor neuron gene 1 (SMN1) (http://www.fsma.org/FSMACommunity/understandingsma/WhatCausesSMA/). In healthy people SMN1 produces a protein known as the survival motor neuron (SMN) protein. In a person with mutated genes, the supply of this protein is absent or is significantly decreased. This results in the deterioration of the nerve cells (motor neurons) connecting the brain and spinal cord to the body’s muscles, therefore causing muscle weakness and gradual loss of movement, because the SMN protein is critical to the survival and health of motor neurons. Spinal muscular atrophy affects 1 in 6000 to 1 in 10000 people. Myasthenia gravis is a unique long-term autoimmune condition which affects the nerves and muscles, resulting in the muscles becoming weak. An autoimmune condition is caused by the immune system mistakenly attacking and destroying healthy body tissue. Ordinarily, the immune systems white blood cells protect the body from harmful substances, known as antigens. For examples: viruses, bacteria, toxins, etc. antibodies are produced as a counter measure by the immune system that destroy the antigens. In people with autoimmune disorder, the immune system has difficulty distinguishing between antigens and healthy body tissue. Due to this an immune system response that kills healthy body tissue is produced. The cause of the immune system no longer being able to distinguish between antigens and healthy body tissue is unknown at present. A theory suggests that drugs or microorganisms (like bacteria or viruses) may trigger some of these changes. In myasthenia gravis, the immune system accidental ly produces antibodies (proteins) that damage or block muscle receptor cells. This stops muscles contracting because the antibodies prevent messages being past from the nerve endings to the muscles. However, it is not understood why the immune system of some people produce antibodies that attack the muscle receptor cells. Symptoms of myasthenia gravis generally include impaired eye movement and weakness of muscles that are voluntarily controlled, therefore affecting functions such as facial expressions, eye and eye lid movement, chewing, talking and swallowing, and weakness of neck and limbs. However since weakness is a common symptom in many different diseases and conditions, diagnosis of myasthenia gravis is normally delayed or missed. Myasthenia gravis is diagnosed through Blood tests, Genetic tests and Electromyogram. In the U.S about 20 in 100,000 people are diagnosed with myasthenia gravis. Presently there is no known cure for MND, SMA, OR MG, however there are treatments that can be initiated with aims to ease symptoms to help the person feel more comfortable and have a better quality of life, and compensate for the gradual loss of bodily functions like mobility, communication, breathing and swallowing. For example, for MND, muscle relaxants can help reduce muscle stiffness; medicines such as phenytoin can treat muscle cramps; a breathing mask can help reduce shortness of breath. Right now, the only available treatment for MND that affects the progression of the disease is Riluzole, however it doesn’t stop the progression of motor neuron disease, but only slows it down by a few months (http://www.nhs.uk/conditions/Motor-neurone-disease/Pages/Introduction.aspx). With SMA, depending on the severity, treatment could involve: exercise, to prevent joint stiffness and improve range of movement and flexibility; assistive equipment such as motorised wheelchairs and walk ing frames if someone with SMA has difficulty moving; nutrition advice and feeding tubes; bracing and surgery to treat scoliosis (curvature of the spine) (http://www.nhs.uk/Conditions/Spinal-muscular-atrophy/Pages/Treatment.aspx). For patients with MG, medication such as pyridostigmine and neostigmine (less common), can prevent the breakdown of acetylcholine, an important chemical that assists the muscles in contracting (http://www.nhs.uk/Conditions/Myasthenia-gravis/Pages/Treatment.aspx). If pyridostigmine is ineffective, steroid tablets can be used to lessen the symptoms. Doctors also often prescribe azathioprine, methotrexate or mycophenolate, to suppress the immune system. Muscle strength can be improved by controlling the production of abnormal antibodies through the use immunosuppressants. In some cases of MG, surgery to remove the thymus gland (a thymectomy) may be recommended. The thymus gland is part of the immune system and is found underneath the breast bone, it is someti mes abnormal in people with MG. In numerous cases, treatment of MG substantially improves muscle weakness allowing a person with the condition to lead a comparatively normal life. Some people may experience permanent or temporally periods where symptoms stop and treatment is no longer needed. Permanent remissions occur in about a third of the people who have a thymectomy (http://www.nhs.uk/Conditions/Myasthenia-gravis/Pages/Treatment.aspx). Currently, the hope of many is that stem cells of extraneural or neural origin might be modified in vitro (i.e. transforming skin cells into induced pluripotent stem cell (iPS)) (http://www.eurostemcell.org/factsheet/motor-neurone-disease-how-could-stem-cells-help) to differentiate into motor neurons that would migrate to sites of motor neuron loss and restore the motor pathways lost in MND by forming functional connections (Boulis, 2011). The most promising cells so far that can be used for stem treatment of MND are spinal cord stem cells, which are able to produce both motor neurons and a cell call glia. Many of the proteins known as growth factors that contribute to motor neurons development are secreted by glia. There is also a possibility that non-neuronal cells such as glia can be used to prevent further damage to motor neurons and encourage repair through the production of the working version of the protein SOD1, which in some types of MND doesn’t function properly (htt p://www.eurostemcell.org/factsheet/motor-neurone-disease-how-could-stem-cells-help). Stem cell therapy also has to the potential to be used as a possible cure for SMA, MG and other neurological conditions. Gene therapy uses genes to prevent or treat a disease by introducing genetic material in cells to compensate for abnormal genes or to make a beneficial protein (MacKenzie, 2010). Gene therapy was found to be well suited as a future treatment for SMA by the Kaspar group: who described a self-complementary (sc) AAV9 vector that crosses the blood-brain barriers after systemic administration; because of scAAV9’s remarkable efficiency in central nervous system (CNS) gene transfer, after intravenous delivery in mice and other larger animals. Using this as a base, the Kaspar group along with Arthur burgees, detail the most successful rescue reported yet in a mouse model of severe SMA. This was achieved by injecting scAAV9 that is carrying SMN1, into the facial vein of mice pups on their day of birth (MacKenzie, 2010). The approach of injecting scAAV9 into mice pups, resulted in the transduction of 40% of motor neurons, and an extension of the lifespan of the mice from 2 weeks to more than 250 days, combined with almost normalised neuromuscular electrophysiology and normal motor function (MacKenzie, 2010). This preliminary data obtained in the gene therapy rescue of SMA in the mouse model, reported by the Kaspar group and Arthur Burghes (a pioneer of SMA), suggests that the same approach could be used in primates. The authors investigated systemic injection of scAAV9-GFP in a cynomolgus monkey (1 day of age). After four weeks, the magnitude of GFP in spinal motor neurons recorded was similar to that shown by the mice (MacKenzie, 2010), boding well for possible application to humans. This news, along with recent encouraging reports of AAV gene therapy of retinal disease, supports the further rehabilitation of gene therapy as a credible therapeutic alternative for neurological diseases, including MG, SMA and MND. The stage seems set: with seemingly untreatable disorders of unknown pathogenesis; an unknown presymptomatic way of diagnosis; and, the small possibility of a cure through gene therapy and stem cell therapy, which are by far the best hopes, not only for MND, SMA and MG, but also for other neurological diseases. However, gene therapy and stem cell therapy are subject to a lot of public disagreement. For gene therapy this is due to fact that, gene therapy targeted at germ cells (egg and sperm cells), (known as germline gene therapy) could be pass on to next generations. Whilst it spares a family and their future generations from a specific genetic disorder, there’s a possibility it could affect the development of a fetus in unexpected ways or have yet unknown long-term side effects (http://ghr.nlm.nih.gov/handbook/therapy/ethics). Because the people who are going to be affected are not yet born, they are unable to choose whether to have the treatment, resulting in big debates on e whether germline gene therapy should be used. Other ethical concerns involve negative impacts on what society thinks is â€Å"normal†, and discrimination toward those with the â€Å"undesirable traits† that arise from using gene therapy as a form â€Å"modification† for unwanted traits or to make â€Å"genetic improvements†. The idea of stem cell therapy is also controversial. Whilst it can used for the treatment of many diseases including neurological ones, there are ethical problems involving how it is obtained. For example, stem cells obtained from the embryo, because the embryo is viewed as a potential person. Due to this, taking stem cells from an embryo is considered to be murder, however, it’s argued that, an early embryo that hasn’t be implanted into the uterus doesn’t have properties we associate with being a person, and therefore can and should be used for the benefit of patients (who are persons). Bibliography: http://ec.europa.eu/health/major_chronic_diseases/diseases/brain_neurological/index_en.htm (20/07/2014) http://www.nhs.uk/conditions/Motor-neurone-disease/Pages/Introduction.aspx (20/07/2014) http://www.patient.co.uk/health/Motor-Neurone-Disease (20/07/2014) http://www.fsma.org/FSMACommunity/understandingsma/WhatCausesSMA/ (04/07/2014) http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/genemutation (20/06/2014) http://biology.about.com/od/basicgenetics/ss/gene-mutation.htm (21/06/2014) http://www.nhs.uk/conditions/Spinal-muscular-atrophy/Pages/Introduction.aspx (20/07/2014) http://www.nhs.uk/Conditions/Spinal-muscular-atrophy/Pages/Treatment.aspx (04/07/2014) http://www.nhs.uk/Conditions/Myasthenia-gravis/Pages/Treatment.aspx (21/07/2014) http://www.eurostemcell.org/factsheet/motor-neurone-disease-how-could-stem-cells-help (05/07/2014) Nicholas M. Boulis. (2011). Gene Therapy for Motor Neuron Disease.Gene Vector Design and Application to Treat Nervous System Disorders. 33 (3), p41-49 Alex MacKenzie. (2010). A severe inherited neuromuscular disease is corrected in mice by intravenous gene delivery.Gene therapy for spinal muscular atrophy. 28 (3), 235-237 http://ghr.nlm.nih.gov/handbook/therapy/genetherapy, (27/06/2014) http://ghr.nlm.nih.gov/handbook/therapy/ethics, (28/06/2014) http://ghr.nlm.nih.gov/handbook/therapy/procedures, (27/06/2014)

World War One the most Important cause of the March Revolution :: WWI WW1

Was World War One the most Important cause of the March Revolution? Nicholas II the eldest son of Alexander III and the Tsar of Russia was born at Krasnoye Selo in May 1868. Nicholas II ruled from 1894 until his abdication in 1917. Nicholas II signed his abdication on 15 March 1917 after the Russian Army High Command recommended it. There are many reasons why Nicholas abdicated including, the financial state of the country, its wide and varied population and their dissatisfaction with the way the country was being ruled. As Russia was already in a weak state and the people had been suffering for many years, the First World War proved the last straw for the Russian people and whilst was possibly not the most important cause was certainly the trigger or catalyst for the March Revolution and Nicholas’ abdication. When The Russian army entered WWI they were huge but poorly led and very badly equipped, there were not enough guns for everyone. They just had lost the war with Japan so heavy casualties meant loss of morale and spirit yet they were expected to go into war again. To make up for the losses in Japan they had to recruit peasants for their army. In a backward country with little money there would have been no chance to train the peasants to be effective soldiers. Their equipment and method of fighting was also no match for the German Army. The Russian’s were trained in charging at the enemy with bayonets, the German troops had machine guns. As a result of this, whilst the Russians were defending the German attack on Poland, half their army was destroyed. Going into a war with such little chance of winning, did nothing to make the Russian people respect Nicholas. The decision that Tsar Nicholas II took in August 1915, to take over the command of the Army, lead to further problems. Being so closely linked to the Army’s failure in the WWI meant even The Duma began to loose faith in his abilities to run the country. Also, while he was away, he left his wife, Alexandra, and Rasputin, a monk who had physic powers who knew when Nicholas’ son was in trouble, to run the country. This was a bad decision Nicholas made because they constantly sacked Ministers and allowed the transport and food problems to descend into crisis. Also Alexandra was half German, when she took charge rumors spread suggesting that she was a German spy. World War One the most Important cause of the March Revolution :: WWI WW1 Was World War One the most Important cause of the March Revolution? Nicholas II the eldest son of Alexander III and the Tsar of Russia was born at Krasnoye Selo in May 1868. Nicholas II ruled from 1894 until his abdication in 1917. Nicholas II signed his abdication on 15 March 1917 after the Russian Army High Command recommended it. There are many reasons why Nicholas abdicated including, the financial state of the country, its wide and varied population and their dissatisfaction with the way the country was being ruled. As Russia was already in a weak state and the people had been suffering for many years, the First World War proved the last straw for the Russian people and whilst was possibly not the most important cause was certainly the trigger or catalyst for the March Revolution and Nicholas’ abdication. When The Russian army entered WWI they were huge but poorly led and very badly equipped, there were not enough guns for everyone. They just had lost the war with Japan so heavy casualties meant loss of morale and spirit yet they were expected to go into war again. To make up for the losses in Japan they had to recruit peasants for their army. In a backward country with little money there would have been no chance to train the peasants to be effective soldiers. Their equipment and method of fighting was also no match for the German Army. The Russian’s were trained in charging at the enemy with bayonets, the German troops had machine guns. As a result of this, whilst the Russians were defending the German attack on Poland, half their army was destroyed. Going into a war with such little chance of winning, did nothing to make the Russian people respect Nicholas. The decision that Tsar Nicholas II took in August 1915, to take over the command of the Army, lead to further problems. Being so closely linked to the Army’s failure in the WWI meant even The Duma began to loose faith in his abilities to run the country. Also, while he was away, he left his wife, Alexandra, and Rasputin, a monk who had physic powers who knew when Nicholas’ son was in trouble, to run the country. This was a bad decision Nicholas made because they constantly sacked Ministers and allowed the transport and food problems to descend into crisis. Also Alexandra was half German, when she took charge rumors spread suggesting that she was a German spy.

Darkness At Noon Essay -- essays research papers

The Saving Grace of Rubashov Despite its brevity Darkness at Noon by Arthur Koestler packs an enormous amount of thought provoking dialog and insight into what may go through the mind of someone who is going through an extreme ordeal. One theme which ran throughout the book was Rubashov’s actions that were taken as matters of self-preservation and what he must do to atone for them. The first instance of this was on page 45 where he asked if it is necessary to pay for deeds that were necessary and right. This was brought on by Rubashov’s attempt and his witnessing of his neighbor’s attempt on his behalf. More is said about this during Rubashov’s first journal entry on page 80. Here he attempts to explain the logic behind the party’s eradication of thought that goes against party doctrine. That the party is in fact more interested in wiping out these ideas which can act as seeds taking root in future generations. Then it is in punishing people. During this entry Rubashov makes no attempt but rather feels that everything shall be sorted out by history. But for him the most painful of all of his sacrifices, was his surrendering of in his secretary and lover, Arlova. Rubashov suffered much as he antagonized over weather this was in fact the correct choice to be made. The pain felt by Rubashov over this decision was amplified by his wi tnessing his old friend being taken much the same way as Avolora. After finishing this book I was amazed at how I did not feel...

An American Family Essay

Critics predicted that â€Å"[b]y the end of the mid-century, the American family will no longer exist as we know it†Ã¢â‚¬â€a line that holds true on the current situation of the country. The image of an American family is as fluid as fashion. This connotation is evident with the number of juvenile delinquents, divorce hearings and domestic violence cases that is reported each day. The advent of democracy and liberalism has perhaps triggered the immense transformation on viewing an American family. Globalization for one, takes the largest piece of this shift. The country’s unbolting wrap on the issue of foreign affairs has created a large impact on every American’s life. Diversity they say, has made the Americans mature. But what most do not realize is that the country has been divided by these ‘borrowed’ or ‘adopted’ ordeals. Similar to the American dream, an American family’s dignifying character has shifted to a somewhat aggressive and liberal type (Glick, 2006). Conceivably, this change can be charged to the saying that the world is in constant flux. However, republicans would resent the changes that has transcribed. Given the percentage of migrating individuals and the increase of Americans going abroad—it is most likely that other culture will blend in (or in the near future dominate) with what is inside the core of American virtues. Simple logic would explain this argument. To date, a laissez faire scenario is occurring. More and more changes are to occur if Americans will not pave a way to keep the tradition. It is a fact that every country has their respective culture, beliefs and tradition. And the endpoint of this matter would either be of the benefit of the alien or of the resident. Hence, the real picture on this squabble marks as to whether these changes have preserved the distinctive quality of an American family or otherwise. And in this case, there is a huge possibility that the picture will be dominated by the visiting forces. The shift is in fast pace—the critics may have predicted the future accurately. Reference Glick, P. C. (2006). The Family Life Cycle and Social ChangeThe Family Life Cycle and Social Change. Family Relations, 38(2).

Minicase San Pico

San Pico is a rapidly growing Latin American developing country. The country is blessed with miles of scenic beaches that have attracted tourists by the thousands in recent years to new resort hotels financed by joint ventures of San Pico businessmen and moneymen from the Middle East, Japan, and the United States. Additionally, San Pico has good natural harbors that are conducive for receiving imported merchandise from abroad and exporting merchandise produced in San Pico and other surrounding countries that lack access to the sea.Because of these advantages, many new businesses are being started in San Pico. Presently, stock is traded in a cramped building in La Cobijio, the nation's capital. Admittedly, the San Pico Stock Exchange system is rather archaic. Twice a day an official of the exchange will call out the name of each of the 43 companies whose stock trades on the exchange. Brokers wanting to buy or sell shares for their clients then attempt to make a trade with one another. This crowd trading system has worked well for over one hundred years, but the government desires to replace it with a new modern system that will allow greater and more frequent opportunities for trading in each company, and will allow for trading the shares of the many new start-up companies that are expected to trade in the secondary market. Additionally, the government administration is rapidly privatizing many state-owned businesses in an attempt to foster their efficiency, obtain foreign exchange from the sale, and convert the country to a more capitalist economy.The government believes that it would conduct this privatization faster and perhaps at more attractive prices if it had a modern stock exchange facility where the shares of the newly privatized companies will eventually trade. You are an expert in the operation of secondary stock markets and have been retained as a consultant to the San Pico Stock Exchange to offer your expertise in modernizing the stock market. What w ould you advise? Explain. Most new and renovated stock exchanges are being established these days as either a partially or fully automated trading system.A fully automated system is especially beneficial for a small to medium size country in which there is only moderate trading in most issues. Such a system that deserves special note is the continuous National Integrated Market system of New Zealand. This system is fully computerized and does not require a physical structure. Essentially all buyers and sellers of a stock enter through their broker into the computer system the number of shares they desire to buy or sell and their required transaction price. The system is updated constantly as new purchase or sale orders are entered into system.The computer constantly searches for a match between buyer and seller, and when one is found a transaction takes place. This type of system would likely serve San Pico’s needs very well. There is existing technology to implement, the bug s have been worked out in other countries, and it would satisfy all the demands of the demands of the San Pico government and easily accommodate growth in market activity MINI CASE: SARA LEE CORP. ’S EUROBONDS The International Finance in Practice boxed reading in the chapter discussed a three-year $100 million Eurobond issue by Sara Lee Corporation.The article also mentions other bond issues recently placed by various foreign divisions of Sara Lee. What thoughts do you have about Sara Lee’s debt financing strategy? Suggested Solution to Sara Lee Corp. ’s Eurobonds Sara Lee is the ideal candidate to issue Eurobonds. The company has worldwide name recognition, and it has an excellent credit rating that allows it to place new bond issues easily. By issuing dollar denominated Eurobonds to Swiss investors, Sara Lee can bring new issues to market much more quickly than if it sold domestic dollar denominated bonds.Moreover, the Eurodollar bonds likely sell at a lower yield than comparable domestic bonds. Additionally, it appears as if Sara Lee is raising funds in a variety of foreign currencies. Sara Lee most likely has large cash inflows in these same currencies that can be used to meet the debt service obligations on these bond issues. Thus Sara Lee is finding a use for some of its foreign currency receipts and does not have to be concerned with the exchange rate uncertainty of these part of its foreign cash inflows.

Benjamin D. Powell

Benjamin D. Powell makes an argument in his paper â€Å"Exploring Mirror Neurons: Rethinking Performance and Communicative Processes† that will make every self-avowed video game dork ecstatic. The concept that by observing an action repeatedly our mirror neurons learn to perform the action will appeal to thousands or even millions who spend their days in front of a television or video screen rather than out experiencing life. Powell adds the caveat that without practicing the action, the body will not be able to perform it with the skill of a trained athlete, but argues that the presence of mirror neurons explains why he was not more injured when hit by a car. The paper claims that the presence of mirror neurons may indicate that more study is needed regarding how our bodies develop skills and what effect activities like playing video games have on our neurological development. At worst, Powell’s theory is an interesting pipe dream. At best, it is hope for the people who spend too much time playing â€Å"World of Warcraft†. Unfortunately, the reality is it seems to be something of a pipe dream. It is much more likely that he simply got lucky when the car hit him and instinctively tucked and rolled. And, the car, which he described as barreling toward him, probably was not moving with the speed he believed it to be.   Writing for the British Journal for the Philosophy of Science, Kathleen Wilkes seems to echo parts of Powell’s basic thesis. (Wilkes 111). She argues that the possibility exists that people are capable of learning simply through observation, but there is no hard science to defend either her statement or Powell’s. The reality is that this is some odd combination of philosophy and science, with people speculating on something that science has yet to be able to measure or prove. In the end, while the philosophy of a mind-body link so deep that the mind can control the body’s actions after merely observing an action seems plausible there is no science to back it up. Powell’s evidence is merely a corollary, coincidental and not direct proof of a tie. To actually prove Powell’s theory would be difficult and complicated. One would have to prove that there was simply no other way, short of mirror neurons that the test subject could have learned to complete a specific action. And, the researcher would have to be able to determine how much of the action and the response to it is based on intellectual knowledge versus muscle knowledge. In short, the researcher would have to prove that simply watching someone swing a bat repeatedly would equate to the ability to do it and that the ability is more than the intellectual knowledge of where to place one’s hands on the bat. He would have to prove that Powell’s escape from injury was more related to his ability to tuck and roll than his knowledge that tuck and roll was the right way to minimize the force of impact of an oncoming car. Ultimately, Powell’s problem becomes in determining what actions are effective because of the mental processes telling us how to do them and which ones are effective because of the muscle knowledge of when to flex or release. Even making the differentiation there could take years. WORKS CITED Powell, Benjamin D. â€Å"Exploring Mirror Neurons: Rethinking Performance and Communicative Processes.† Wilkes, Kathleen V. â€Å"Brain States†Ã‚   The British Journal for the Philosophy of Science, Vol. 31, No.2. June, 1980. pp. 111-129.   

1984- Orwel’s Parallelism to Modern Times Essay

Orwell wrote at a time when communism seemed likely to spread across the word, which is a similar situation that we see today in some countries. Studying the Orwell’s works is relevant as it parallels with modern times. Orwell’s writing mostly focused on the nature of human in the society; his opinion about the non-democratic world and central authority focused in social and political areas. He wanted to educate people and expose everything he was against. Through the use of symbolism, extended metaphors and intensive imagery, Orwell wrote â€Å"naturalistic novels with unhappy endings, full of detailed descriptions and arresting similes† (Orwell, Why I Write) thus turning his harsh words into an art form. In his essay, ‘Why I Write’, Orwell stated that he wanted to capture the truth of human nature. As exemplified in his story of poverty, Down and out in Paris and London; he captured the realism of life during the Spanish Civil War in Homage to Catalonia, and in The Road to Wigan Pier, Orwell studied human misery in an exploitative social order. In 1984, Orwell described utter and total hatred to people who are different, hate of evil and hate of all other humans. It is where love is described as absurd, and totally unnecessary. People are raised to hate, and hate is the primary emotion that people feel. The lack of love and kindness is what brings the society to a complete totalitarian state. Human beings instinctively crave love and care to thrive; without it, no one can experience happiness or freedom. This works well for 1984 because of its hate-driven society; however the lack of love causes unrest with those who can see the importance of love. Orwell’s non-fictional works greatly differ from his fictional works though; they both constitute the same understanding of human decency. His fictional works contained many details with the use of imagery, themes and symbolism. On the other hand, Orwell’s non-fictional works is structured differently as he utilized a first person point of view, colloquial diction and a tone that points out the moral decency of humanity. Orwell’s trend in his writing, since 1936, had been directly and indirectly against totalitarianism and for democratic socialism. Orwell confessed that he wrote â€Å"because there [was] some lie that [he wanted] to expose, some fact to which [he wanted] to draw attention, and [his] initial concern [was] to get a hearing [in the world’s politics]† (Orwell, Why I Write). While Communism might have exited the world stage in terms of competing for dominance, there needed to be a mindful and attentive presence taken against what happened when a central authority took over. Orwell didn’t criticize the act of revolution itself but the misery it could cause if the leaders grow to be corrupt, shortsighted, greedy and indifferent. He wanted to expose the most important issue that affected everyone in the world. Animal Farm was the first book he wrote to expose the Soviet myth of socialism. Even in his finest fictional novels, Orwell conveys the same basis of human reality. Nineteen Eighty-Four explored his hatred towards totalitarianism and government security. Animal Farm was his satirical, allegorical and metaphorical masterpiece elucidating his abhorrence of Stalin’s dictatorship in the Soviet Union. Orwell’s use of symbolism in 1984 reveals more about what he wanted to portray in a new creative way. His use of symbolism allowed readers to easily understand his message as well as appreciate his writing style simultaneously. For example, in 1984 Orwell used Big Brother as a symbol to represent the Party. The citizens were told that Big Brother is the leader of the nation and the head of the Party, but Winston could never determine whether or not he actually existed. In any case, the face of Big Brother symbolized the Party in its public manifestation; he is a reassurance to most people (the warmth of his name suggests his ability to protect), but he is also an open threat (one cannot escape his gaze). Big Brother also symbolizes the vagueness with which the higher ranks of the Party presented themselves—readers are left wondering who really rules Oceania, what life is like for the rulers, or why they act as they do. Additionally, in Animal Farm he used the farm to symbolize Russia and the Soviet Union under a Communist Party rule. Generally, Animal Farm stands for any human society are it capitalist, socialist, fascist, or communist. The farm reflects the dynamics of a nation represented by animals: the government (the pigs), the police force or army as the dogs and the working class as the other animals. Its location amid a number of hostile neighboring farms supports its symbolism as a political entity with diplomatic concerns. Orwell portrayed detailed symbolism in 1984 and Animal Farm, keeping both novels renowned up to the day. Orwell remains an important author as his themes reoccur in the twentieth century. His writing gives a sense of how life is a struggle but it is not to be feared – that fitting in and belonging need not be the most important goals in life. Orwell was willing to go out there and fight in trenches for what we believed and he wrote about what he thought was important. He was a great representational novelist, as seen in Nineteen Eighty-Four, for portraying the realities of mundane life in totalitarian societies in such original and artistic manner.